Harvard Tissue Atlas Harvard Medical School
Data

Atlas Datasets

HTA data is currently organized by the original publication. Our goal is to incorporate these data into multi-functional Atlases. Over time search and other means of accessing data will be added.

Featured Publications

Multimodal spatial profiling reveals immune suppression and microenvironment remodeling in fallopian tube precursors to high-grade serous ovarian carcinoma

Multimodal spatial profiling reveals immune suppression and microenvironment remodeling in fallopian tube precursors to high-grade serous ovarian carcinoma

Kader T, Lin J-R, Hug C, Coy S, Chen Y-A, de Bruijn I, Shih N, Jung, E, ... Santagata S
Cancer Discovery. 2024 Dec 20. https://doi.org/10.1158/2159-8290.CD-24-1366
AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

Schade A, Perurena N, Yang Y, Rodriguez CL, Krishnan A, Loi P, Mastellone GM, Pilla NF,... Cichowski K. (2024).
Nature. https://doi.org/10.1038/s41586-024-08031-6
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution.

The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution.

Nirmal AJ, Maliga Z, Vallius T, Quattrochi B, Chen AC, Jacobson CA, Pelletier RJ,... Lian CG, Murphy GF, Santagata S, Sorger, PK. (2022)
Cancer Discovery, 12(6), 1518–1541. https://doi.org/10.1158/2159-8290.CD-21-1357
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer

Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer

Guerriero JL, Lin JR, Pastorello RG, Du Z, Chen YA, Townsend M, Shimada K, Hughes ME ... Santagata S (2024).
npj Breast Cancer, 10(2). https://doi.org/10.1038/s41523-023-00605-3
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers.

High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers.

Lin JR, Chen YA, Campton D, Cooper J, Coy S, Yapp C, Tefft JB, McCarty E,...Sorger PK (2023).
Nature Cancer https://doi.org/10.1038/s43018-023-00576-1
Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer.

Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer.

Lin J-R, Wang S, Coy S, Tyler M, Yapp C, Chen Y-A, Heiser CN, Lau KS, Santagata S, Sorger PK. (2023).
Cell, 186(19), 363-381.e19. https://doi.org/10.1016/j.cell.2022.12.028
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.

Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.

Mehta AK, Cheney EM, Hartl CA, Pantelidou C, Oliwa M, Castrillon JA, Lin, J-R,... Guerriero, J. (2021).
Nature Cancer, 2(1), 66–82. https://doi.org/10.1038/s43018-020-00148-7
Temporal and spatial topography of cell proliferation in cancer.

Temporal and spatial topography of cell proliferation in cancer.

Gaglia G, Kabraji S, Angyropoulu D, Dai Y, Wang S, Bergholz J, Coy S, Lin J-R, ... Santagata, P. (2022).
Nature Cell Biology, 24(3), 316-326 https://doi.org/10.1038/s41556-022-00860-9

Other Publications

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients.

Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients.

Wu H-J, Temko D, Maliga M, Moreira A, Sei E, Conterno Minussi D, Dean J, Lee C, Xu Q,... Michor F. (2022).
Cell Genomics, 2(8), 100165. https://doi.org/10.1016/j.xgen.2022.100165
A human breast atlas integrating single-cell proteomics and transcriptomics.

A human breast atlas integrating single-cell proteomics and transcriptomics.

Gray GK, Li CM-C, Rosenbluth JM, Selfors LM, Girnius N, Lin J-R, Schackmann RCJ, Goh WL, Moore K,...Brugge JS. (2022).
Developmental Cell, 57(22), 1400-1420. https://doi.org/10.1016/j.devcel.2022.05.003
The immunoregulatory landscape of human tuberculosis granulomas.

The immunoregulatory landscape of human tuberculosis granulomas.

McCaffrey EF, Donato M, Keren L, Chen Z, Delmastro A, Fitzpatrick MB, Gupta S, Greenwald NF,... Angelo M. (2022).
Nature Immunology, 23(2):318–329. https://doi.org/10.1038/s41590-021-01121-x
Evolution of delayed resistance to immunotherapy in a melanoma responder.

Evolution of delayed resistance to immunotherapy in a melanoma responder.

Liu D, Lin J-R, Robitschek EJ, Kasumova GG, Heyde A, Shi A, Kraya A,... Boland, GM. (2021).
Nature Medicine, 27, 985–992. https://doi.org/10.1038/s41591-021-01331-8
Clinical efficacy and molecular response correlates of the WEE1 inhibitor adavosertib combined with cisplatin in patients with metastatic triple-negative breast cancer.

Clinical efficacy and molecular response correlates of the WEE1 inhibitor adavosertib combined with cisplatin in patients with metastatic triple-negative breast cancer.

Keenan TE, Li T, Vallius T, Guerriero JL, Tayob N, Kochupurakkal B, Davis J, Pastorello R,... Tolaney SM. (2021).
Clinical Cancer Research, 2(1), 66-82. https://doi.org/10.1158/1078-0432.CCR-20-3089
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging.

Du Z, Lin J-R, Rashid R, Maliga Z, Wang S, Aster JC, Izar B, Sorger PK, Santagata S. (2019).
Nature Protocols, 14(10), 2900–2930. https://doi.org/10.1038/s41596-019-0206-y
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-cycif and conventional optical microscopes.

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-cycif and conventional optical microscopes.

Lin J-R, Izar B, Wang S, Yapp C, Mei S, Shah PM, Santagata S, Sorger, PK. (2018).
ELife, 7. https://doi.org/10.7554/eLife.31657