Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers together image and omic datasets into molecular maps. Our atlases bring together multiple research projects examining normal and diseased tissue from human and animal models, with an emphasis on cancer. The goal of these atlases is to describe the myriad of interactions that occur between cells and acellular structures within tissues to advance our understanding of disease initiation and progression. This will help develop a new generation of diagnostic molecular tests, which are needed for disease stratification in clinical trials and precision medicine for patients.
News
'Multiplexed 3D atlas' selected as the Best of Cell 2023
News
'High-plex immunofluorescence imaging' featured in Nature Cancer’s 2023 in Review
News
Live Cell Imaging IDs Bad Actors in Cancer and Finds Possible Ways to Defeat Them
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A New Tool for Diagnosing Cancer
News
New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
News
Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
News
An Unprecedented Look at Colorectal Cancer
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Getting Under Our Skin
News
Publications & Software
Development and validation of time-to-event models to predict metastatic recurrence of localized cutaneous melanoma
Publication
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
Publication
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Publication
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication
Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients
Publication
Minerva
A suite of software tools for interpreting, interacting with, and sharing complex image data.
Software
The spatial landscape of progression and immunoediting in primary melanoma at single cell resolution
Publication
Software
MCMICRO: A multiple-choice microscopy pipeline
An end-to-end processing pipeline for multiplexed whole tissue imaging and tissue microarrays.
Publication
Software