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The Omic and Multidimensional Spatial (OMS) Atlas

The OMS Atlas Center based at the Oregon Health Sciences University (OHSU) and led by Joe Gray is a component of the National Cancer Institute Human Tumor Atlas Network (HTAN), a multi-center program within the National Cancer Institute that emerged from the Beau Biden Cancer Moonshot Initiative. All data associated with HTAN can be found at the Human Tumor Atlas. Our team us a collaborator on the OMS Atlas focusing on the application of multi-dimensional CyCIF imaging methods to clinical trial samples.

The OMS is focused on elucidating mechanisms of therapy resistance in three clinical scenarios in which disease recurrence is a major concern: (a) hormone-receptor positive breast cancer (HRBC) undergoing treatment with a CDK4/6 inhibitor in combination with endocrine therapy, (b) triple negative breast cancer (TNBC) undergoing treatment with a PARP inhibitor and an immunomodulatory agent (c) castration resistance prostate cancer (CRPC) undergoing treatment with enzalutamide. Diverse imaging and omic methods are being applied to this analysis including several complementary ways to create spatial maps of cell types and states. These include multiplex immuno-histochemistry, CyCIF, Focused Ion Beam Scanning Electron Microscope (FIB-SEM).

Principal Investigators

  • Jeremy Goecks, PhD, Associate Professor of Biomedical Engineering and Computational Biology, Oregon Health and Science University
  • Joe Gray, PhD, Professor Emeritus of Biomedical Engineering, Oregon Health and Science University
  • Gordon Mills, MD PhD, Professor of Cell, Developmental and Cancer Biology, Oregon Health and Science University
  • Sandro Santagata, MD PhD, Associate Professor of Pathology, Brigham and Women’s Hospital and Harvard Medical School
  • Peter Sorger, PhD, Professor of Systems Biology, Harvard Medical School
  • George Thomas, MD, Professor of Pathology and Laboratory Medicine, Oregon Health and Science University

Funding

The OMS Center at Harvard Medical School is funded by a Human Tumor Atlas Network grant U2C-CA233280 (Joe Gray PI) from the National Cancer Institute “Omic and Multidimensional Spatial (OMS) Atlas”.