Tissue and tumor atlases revolutionize our understanding of disease progression and therapeutic response. They provide precise molecular data on cell types, states, and interactions in a preserved 3D environment to improve diagnosis and disease management.
Navigating Spatial Biology
The Harvard Tissue Atlas (HTA) gathers image and -omic datasets into high-resolution molecular maps. Our atlases provide precise molecular data on cell types, states, and interactions in a preserved 3D environment, shedding light on the complex interactions between cellular and acellular structures in normal and diseased tissue. These data provide a deeper understanding of how diseases start and progress to improve disease diagnosis and management.
The Harvard Tissue Atlas datasets enable a foundation for future advances in precision medicine, such as early cancer detection, AI/ML predictive models, and disease stratification for clinical trials.
Atlases
News
'Multiplexed 3D atlas' selected as the Best of Cell 2023
News
'High-plex immunofluorescence imaging' featured in Nature Cancer’s 2023 in Review
News
Live Cell Imaging IDs Bad Actors in Cancer and Finds Possible Ways to Defeat Them
News
A New Tool for Diagnosing Cancer
News
New 3D Atlas of Colorectal Cancer Promises Improved Diagnosis, Treatment
News
Ludwig Harvard imaging study reveals cellular, molecular and structural complexity of colorectal tumors
News
An Unprecedented Look at Colorectal Cancer
News
Getting Under Our Skin
News
Publications & Software
Development and validation of time-to-event models to predict metastatic recurrence of localized cutaneous melanoma
Publication
Qualification of a multiplexed tissue imaging assay and detection of novel patterns of HER2 heterogeneity in breast cancer
Publication
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
Publication
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Publication
Featured Data Explorations
Nuclear envelope atypia and rupture in human glioblastoma
Multimodal spatial profiling of colorectal cancer using Orion
Graphical Abstract - Multiplexed 3D atlas of state transitions and immune interactions in colorectal cancer
Exploring the Stages of Tuberculosis Granulomas
Deep Exploration of a Primary Melanoma (MEL 1 Full Story)
Patient 2 - Melanoma in situ, invasive melanoma, precursor field and inflammatory regression
BRCA wild-type TNBC vs BRCA1-associated TNBC
Data analysis of primary lung cancer (Lung 3)