Tuberculosis Granuloma Atlas

The Tuberculosis Granuloma Atlas aims to understand the biology of granulomas, sites of chronic lung inflammation shaped by the biology Mycobacterium tuberculosis (Mtb) and host immune responses. Within a granuloma, Mtb growth is often limited, but this provides a niche from which bacteria can subsequently disseminate. The project also aims to build capacity for digital pathology in low and middle income countries (LIMC) including the eventual deployment of Atlas viewers and analysis modules on cell phones. As part of the Atlas, LSP investigators are assembling a cloud-based Tuberculosis Data Resource that will consolidate a rich collection of imaging and genomic data on TB granulomas and make the data publicly available.

Principal Investigators

• Bree Aldridge, PhD, Associate Professor, Molecular Biology and Microbiology, Tufts University School of Medicine
• Amanda Martinot, DVM MPH DACVP, Assistant Professor of Infectious Diseases and Global Health, Tufts University
• Jyothi Rengarajan, PhD, Professor, Division of Infectious Diseases, Emory University School of Medicine
• Peter Sorger, PhD, Professor of Systems Biology, Harvard Medical School

Introduction to TB Granuloma

Narrated Minerva Stories

Narrated stories use multi-step narrations and annotations to walk a viewer through key features of the data. Narrated stories distill the multidisciplinary knowledge encompassed by each dataset into a single product that grounds the scientific analyses in the underlying data and metadata. Click the Minerva story icon for an interactive view of the full-resolution images.

Exploring the Stages of Tuberculosis Granulomas

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Clinical Features of Tuberculosis Granulomas

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Curated Minerva Stories

Curated stories provide access to images that have undergone a quality control step to remove failed markers, ensure appropriate channel intensity settings, and provide metadata about the underlying sample and image. Click the Minerva story icon for an interactive view of the full-resolution images.

TB - MIBI - Patient 15-2

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TB - MIBI - Patient 15-1

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TB - MIBI - Patient 14-2

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TB - MIBI - Patient 14-1

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TB - MIBI - Patient 13-2

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TB - MIBI - Patient 13-1

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TB - MIBI - Patient 12-2

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TB - MIBI - Patient 12-1

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TB - MIBI - Patient 11-2

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TB - MIBI - Patient 11-1

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TB - MIBI - Patient 10-2

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TB - MIBI - Patient 10-1

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TB - MIBI - Patient 9-2

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TB - MIBI - Patient 9-1

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TB - MIBI - Patient 8-2

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TB - MIBI - Patient 8-1

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TB - MIBI - Patient 7-2

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TB - MIBI - Patient 7-1

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TB - MIBI - Patient 6-2

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TB - MIBI - Patient 6-1

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TB - MIBI - Patient 5-2

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TB - MIBI - Patient 5-1

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TB - MIBI - Patient 4-2

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TB - MIBI - Patient 4-1

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TB - MIBI - Patient 3-2

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TB - MIBI - Patient 3-1

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TB - MIBI - Patient 2-2

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TB - MIBI - Patient 2-1

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TB - MIBI - Patient 1-2

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TB - MIBI - Patient 1-1

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Funding

The Atlas is part of a sustained effort by the Bill and Melinda Gates Foundation to understand and ultimately eradicate TB (Funded by Grant INV-027106) and NIH 1R01-AI166305.